Although it has been used in medicine by man for several thousand years, antimony is found to be non-essential and toxic to human body. However, the toxicity of antimony is also expected to be specie and form dependent. Elemental antimony is more toxic than its salt, and trivalent Sb is generally ten times more toxic than pentavalent Sb species. Antimony trioxide is found to cause serious lung cancer by inhalation.  Whereas some antimony containing salts are commonly used as therapeutic treatment of parasite such as leishmaniasis.  The concentration and more importantly the speciation of antimony must be understood before its toxicity can be assessed.

P S Analytical offer both Agilent and Dionex options for the separation of antimony species using the PSA 10.055 Millennium Excalibur as the detector.

PSA 10.825 ISOCRATIC LC SYSTEM FOR THE SPECIATION OF ANTIMONY

The separation of SbIII and SbV can be carried out in less than 3 minutes using a simple isocratic elution program and a strong anion exchange column (PSA C1 or equivalent).

The system offers reliability and ease-of-use and gives limits of detection of 0.2 ng ml-1, making it a useful tool for any laboratory interested in antimony speciation.

This system consists of a 1200 series Isocratic pump, manual injection valve and solvent cabinet. By adding this system to a PSA 10.055 Millennium Excalibur, a PC and a suitable column the user has a powerful analytical tool for antimony speciation.

The 1200 series pump is made of robust materials to withstand the most demanding of solvent compositions. The seal wash option for high salt mobile phaseskeeps maintenance to a minimum, thereby providing lower operational costs.

The system can be enhanced by the C723I009 ChemStation base software. This software is the industries' most widely sold data system.

PSA 10.826 ISOCRATIC LC SYSTEM FOR THE SPECIATION OF ARSENIC

This system consists of a 3100 series Isocratic pump, manual injection valve and solvent rack. By adding this system to a PSA 10.055 Millennium Excalibur, a PC and a suitable column the user has a powerful analytical tool for antimony speciation.

The 3100 series pump is made of robust materials to withstand the most demanding of solvent compositions. The seal wash option for high salt mobile phases keeps maintenance to a minimum, thereby providing lower operational costs.

The system can be enhanced by the addition of Chromeleon software which offers control and data handling including integration facilities.

Other systems are available if additional facilities like degassing or quaternary mixing are required.

All of these systems provide the ideal platform for labs that need an easy-to-learn and easy-to-use system, which can be scaled up and extended as the labs needs grow.

Chromatogram of Five Consecutive Injection of 5 ng ml^-1 Antimony Standards

The chromatogram below shows consecutive injections of 5 ng ml-1 mixed standards of Sb (V) and Sb (III).

Species in real samples are identified on the basis of their retention times.  Precision for the two species is below 5% RSD, and limits of detection for Sb (V) and Sb (III) are in the order of 0.7 and 0.5 ng ml-1, respectively.

To discuss particular requirements and for more detailed information on the above products please complete the Information Request Form.

For information on the speciation of Mercury, Arsenic and Selenium please follow the appropriate link below:

Mercury

Arsenic

Selenium